Albania and Macedonia are neighbouring countries, but the level of trade between them is the lowest. The cross-border Start-Ups and SMEs, apart from underdeveloped physical infrastructure, are characterized with high level of immigration and the existing businesses are on the lower scale of technological development and competitiveness. Whereas the educational institutions provide formal education, including curricula that support self-employment. On the other hand, genuine innovation-led programmes are absent, leaving many young people with no option but to look forward to working for someone else of outside the country. Also business often attribute the lack of quality of human resources to inappropriate or old-fashioned curricula at educational institutions. Besides the old mentioned infrastructure limiting communication in cross border area, there is a need to increase the link between education and business entities which will be enabled through this project. The business will benefit form utilizing the services of the innovation hub, either to cooperate with innovative Start-Ups funded through hub or directly access information that will bring about greater growth in target area. Whereas the higher education institutions will serve as a key driver for technological development of enterprises in every country, share weak knowledge at all sectors. “Entrepreneurial universities” may provide flexible educational curricula focusing mainly on technology utilization.